Familial associations of Alzheimer disease and essential tremor with Parkinson disease
Identifieur interne : 000718 ( Main/Exploration ); précédent : 000717; suivant : 000719Familial associations of Alzheimer disease and essential tremor with Parkinson disease
Auteurs : S. Costello [États-Unis] ; Y. Bordelon [États-Unis] ; J. Bronstein [États-Unis] ; B. Ritz [États-Unis]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2010-06.
English descriptors
Abstract
Background: We constructed a cohort of first‐degree relatives of participants in a population‐based case–control study of Parkinson disease (PD) and compared the occurrence of Alzheimer disease (AD) and essential tremor (ET) in relatives of PD cases and controls. Methods: We relied on proband interviews to assess family history in 372 probands with incident PD confirmed by a movement disorder specialist and 404 controls from three rural California counties. Results: Overall, for the 2980 first‐degree relatives of PD cases, the risk of AD was not increased compared with the 2981 relatives of controls. But relatives of younger onset PD cases (≤60 years of age) were three times more likely to have received an AD diagnosis [hazard ratios (HR): 2.86; 95%CI: 1.44, 5.71]. Our data also suggest that some relatives of PD probands might be at a slightly increased risk of receiving an ET diagnosis, especially relatives of tremor dominant cases (HR: 1.69; 95%CI 0.99, 2.88), younger onset cases (HR: 2.03; 95%CI 0.93, 4.44), and male relatives (HR: 2.31; 95%CI 1.13, 4.73). In addition, fathers of cases were almost 15 years younger than fathers of controls when diagnosed with ET. Results were stable in sensitivity analyses. Conclusion: Our study suggests a familial susceptibility to AD amongst first‐degree relatives of younger onset PD cases.
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DOI: 10.1111/j.1468-1331.2010.02974.x
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Costello</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bordelon, Y" sort="Bordelon, Y" uniqKey="Bordelon Y" first="Y." last="Bordelon">Y. Bordelon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bronstein, J" sort="Bronstein, J" uniqKey="Bronstein J" first="J." last="Bronstein">J. 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Ritz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-06">2010-06</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="871">871</biblScope><biblScope unit="page" to="878">878</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">AA7D93FCEBE7E8B94879BE20EE7D755690071F77</idno><idno type="DOI">10.1111/j.1468-1331.2010.02974.x</idno><idno type="ArticleID">ENE2974</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Parkinson disease</term><term>epidemiology</term><term>familial aggregation</term><term>tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: We constructed a cohort of first‐degree relatives of participants in a population‐based case–control study of Parkinson disease (PD) and compared the occurrence of Alzheimer disease (AD) and essential tremor (ET) in relatives of PD cases and controls. Methods: We relied on proband interviews to assess family history in 372 probands with incident PD confirmed by a movement disorder specialist and 404 controls from three rural California counties. Results: Overall, for the 2980 first‐degree relatives of PD cases, the risk of AD was not increased compared with the 2981 relatives of controls. But relatives of younger onset PD cases (≤60 years of age) were three times more likely to have received an AD diagnosis [hazard ratios (HR): 2.86; 95%CI: 1.44, 5.71]. Our data also suggest that some relatives of PD probands might be at a slightly increased risk of receiving an ET diagnosis, especially relatives of tremor dominant cases (HR: 1.69; 95%CI 0.99, 2.88), younger onset cases (HR: 2.03; 95%CI 0.93, 4.44), and male relatives (HR: 2.31; 95%CI 1.13, 4.73). In addition, fathers of cases were almost 15 years younger than fathers of controls when diagnosed with ET. Results were stable in sensitivity analyses. Conclusion: Our study suggests a familial susceptibility to AD amongst first‐degree relatives of younger onset PD cases.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Costello, S" sort="Costello, S" uniqKey="Costello S" first="S." last="Costello">S. Costello</name></region><name sortKey="Bordelon, Y" sort="Bordelon, Y" uniqKey="Bordelon Y" first="Y." last="Bordelon">Y. Bordelon</name><name sortKey="Bronstein, J" sort="Bronstein, J" uniqKey="Bronstein J" first="J." last="Bronstein">J. Bronstein</name><name sortKey="Ritz, B" sort="Ritz, B" uniqKey="Ritz B" first="B." last="Ritz">B. Ritz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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